synthesis and antimicrobial activity of some 2-[(4-substituted-phenyl-3-chloro-azetidin-2-one)-5-(2'-methylamino-4-phenyl-1', 3'-thiazolyl-]-1, 3,4-thiadiazoles

نویسندگان

s.d. srivastava

چکیده

a new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. the synthesised compounds have been screened in vitro for their antimicrobial activity against bacillus subtilis, escherichia coli. klebsiella pneumoniae and streptococcus aureus bacteria and aspergillus niger, aspergillus flavus, fusarium oxisporium and trichoderma viride fungi respectively. some of the compounds displayed pronounced biological activity.

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منابع مشابه

Synthesis and Antimicrobial Activity of Some 2-[(4-Substituted-Phenyl-3-Chloro-Azetidin-2-One)-5-(2'-Methylamino-4-Phenyl-1', 3'-Thiazolyl-]-1, 3,4-Thiadiazoles

A new 2-[(4-substituted-phenyl-3-chloroazetidin-2-one)-5-(2'-methylamino 4-phenyl-1', 3'-thiazolyl-]-1, 3, 4-thiadiazoles, 5(a-n) were synthesized from 2-substituted-benzylideneamino-5-[2'-methylamino-4'-phenyl-1',3'-thiazolyl]-1,3, 4-thiadiazole, 4(a-n) using 2-amino-4phenyl-1, 3-thiazole as a starting material. The synthesised compounds have been screened in vitro for their antimicrobial acti...

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عنوان ژورنال:
journal of sciences, islamic republic of iran

ناشر: university of tehran

ISSN 1016-1104

دوره 20

شماره 3 2009

کلمات کلیدی
[ 2 , ' a m i n o ' , 4 , ' p h e n y l ' , 1 3 , ' t h i a z o l e ' , ' a n t i m i c r o b i a l a c t i v i t y ' , ' a r y l i d e n e ' , ' t h i a d i a z o l e ' ]

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